Attractive forces between anisotropic inclusions in the membrane of a vesicle

Attractive forces between anisotropic inclusions in the membrane of a vesicle The fluctuation-induced interaction between two rod-like, rigid inclusions in a fluid vesicle is studied by means of canonical ensemble Monte Carlo simulations. The vesicle membrane is represented by a triangulated network of hard spheres. Five rigidly connected hard spheres form rod-like inclusions that can leap between sites of the triangular network. Their effective interaction potential is computed as a function of mutual distance and angle of the inclusions. On account of the hard-core potential among these, the nature of the potential is purely entropic. Special precaution is taken to reduce lattice artifacts and the influence of finite-size effects due to the spherical geometry. Our results show that the effective potential is attractive and short-range compared with the rod length L. Its well depth is of the order of κ/10, where κ is the bending modulus.